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Apr 30, Author: Current primary recommendations for non-metastatic anal cancer include concurrent chemotherapy and radiation therapy. There is some controversy regarding substituting cisplatin for mitomycin in limited-stage disease conflicting clinical trial results ; the National Comprehensive Cancer Network NCCN lists 5FU plus cisplatin and radiation therapy as a category 2B rcommendation. Additional RT of Gy may be considered for patients with T3, T4, or node-positive disease or in those with residual disease after an initial 45 Gy. Metastatic disease is commonly treated with platinum-based chemotherapy.

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